From: iStable: off-the-shelf predictor integration for predicting protein stability changes
RSA range | Predictors | Sn | Sp | Acc | MCC |
---|---|---|---|---|---|
Buried | Â | Â | Â | Â | Â |
 | iStable | 0.640 | 0.946 | 0.869 | 0.634 |
 | I-Mutant_PDB | 0.197 | 0.942 | 0.757 | 0.208 |
 | I-Mutant_SEQ | 0.394 | 0.947 | 0.809 | 0.428 |
 | AUTO-MUTE_RF | 0.387 | 0.988 | 0.839 | 0.528 |
 | AUTO-MUTE_SVM | 0.254 | 0.989 | 0.806 | 0.403 |
 | MUPRO_SVM | 0.445 | 0.922 | 0.803 | 0.423 |
 | PoPMuSiC2.0 | 0.201 | 0.969 | 0.778 | 0.285 |
 | CUPSAT | 0.381 | 0.822 | 0.714 | 0.209 |
Partially buried | Â | Â | Â | Â | Â |
 | iStable | 0.684 | 0.954 | 0.854 | 0.684 |
 | I-Mutant_PDB | 0.458 | 0.911 | 0.746 | 0.427 |
 | I-Mutant_SEQ | 0.537 | 0.940 | 0.792 | 0.542 |
 | AUTO-MUTE_RF | 0.604 | 0.981 | 0.843 | 0.665 |
 | AUTO-MUTE_SVM | 0.510 | 0.967 | 0.799 | 0.566 |
 | MUPRO_SVM | 0.508 | 0.905 | 0.759 | 0.460 |
 | PoPMuSiC2.0 | 0.146 | 0.963 | 0.667 | 0.189 |
 | CUPSAT | 0.536 | 0.781 | 0.692 | 0.323 |
Exposed | Â | Â | Â | Â | Â |
 | iStable | 0.782 | 0.920 | 0.853 | 0.712 |
 | I-Mutant_PDB | 0.527 | 0.818 | 0.683 | 0.363 |
 | I-Mutant_SEQ | 0.502 | 0.927 | 0.728 | 0.480 |
 | AUTO-MUTE_RF | 0.598 | 0.993 | 0.807 | 0.653 |
 | AUTO-MUTE_SVM | 0.565 | 0.933 | 0.760 | 0.543 |
 | MUPRO_SVM | 0.665 | 0.902 | 0.788 | 0.587 |
 | PoPMuSiC2.0 | 0.439 | 0.857 | 0.658 | 0.329 |
 | CUPSAT | 0.513 | 0.661 | 0.592 | 0.177 |