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Table 9 Comparison of performance based on RSA range

From: iStable: off-the-shelf predictor integration for predicting protein stability changes

RSA range Predictors Sn Sp Acc MCC
Buried      
  iStable 0.640 0.946 0.869 0.634
  I-Mutant_PDB 0.197 0.942 0.757 0.208
  I-Mutant_SEQ 0.394 0.947 0.809 0.428
  AUTO-MUTE_RF 0.387 0.988 0.839 0.528
  AUTO-MUTE_SVM 0.254 0.989 0.806 0.403
  MUPRO_SVM 0.445 0.922 0.803 0.423
  PoPMuSiC2.0 0.201 0.969 0.778 0.285
  CUPSAT 0.381 0.822 0.714 0.209
Partially buried      
  iStable 0.684 0.954 0.854 0.684
  I-Mutant_PDB 0.458 0.911 0.746 0.427
  I-Mutant_SEQ 0.537 0.940 0.792 0.542
  AUTO-MUTE_RF 0.604 0.981 0.843 0.665
  AUTO-MUTE_SVM 0.510 0.967 0.799 0.566
  MUPRO_SVM 0.508 0.905 0.759 0.460
  PoPMuSiC2.0 0.146 0.963 0.667 0.189
  CUPSAT 0.536 0.781 0.692 0.323
Exposed      
  iStable 0.782 0.920 0.853 0.712
  I-Mutant_PDB 0.527 0.818 0.683 0.363
  I-Mutant_SEQ 0.502 0.927 0.728 0.480
  AUTO-MUTE_RF 0.598 0.993 0.807 0.653
  AUTO-MUTE_SVM 0.565 0.933 0.760 0.543
  MUPRO_SVM 0.665 0.902 0.788 0.587
  PoPMuSiC2.0 0.439 0.857 0.658 0.329
  CUPSAT 0.513 0.661 0.592 0.177