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Table 5 The top 5 false positive predictions made by GOstruct.

From: Combining heterogeneous data sources for accurate functional annotation of proteins

Protein GOstruct Prediction/Current Annotation (if dierent) Best Supporting Sentence Pubmed ID GO term(s) in Supporting Sentence Evidence Code
MGI:103293 GO:0016787 hydrolase activity We recently demonstrated that human protein tyrosine phosphatase (PTP) L1, a large cytoplasmic phosphatase also known as PTP-BAS/PTPN13/PTP-1E, is a negative
regulator of IGF-1R/IRS-1/Akt path-way in breast cancer cells.
19782949 GO:0004722 IEA
MGI:103305 GO:0016787 hydrolase activity/N/A N/A N/A N/A N/A
MGI:104597 GO:0016740 transferase activity/N/A Using this assay system, chloramphenicol acetyltransferase activity directed by the cTNT promoter/upstream region was between two and three orders of magnitude higher in cardiac or skeletal muscle cells than in fibroblast cells, indicating that cis elements responsible for cell-specific expression reside in this region of the cTNT gene. Many Andersen syndrome cases have been associated with loss-of-function mutations in the inward rectifier K(+) channel Kir2.1 encoded by KCNJ2. 3047142 GO:0008811
GO:0016407
N/A
MGI:104744 GO:0022857 transmembrane transporter activity/GO:0005242 inward rectifier
potassium
channel activity
  18690034 GO:0015267 IEA
MGI:104744 GO:0022892 substrate-specific transporter activity/GO:0005242 inward rectifier potassium
channel activity
IRK1, but not GIRK1/GIRK4 channels, showed a marked specificity toward phosphates in the 4,5 head group positions. 10593888 GO:0015267 IEA
  1. We present the best supporting sentence for the function of each protein, the document source, and the most recent known annotation along with the associated evidence code.