Table 5 The top 5 false positive predictions made by GOstruct.

MGI:103293

GO:0016787 hydrolase activity

We recently demonstrated that human protein tyrosine phosphatase (PTP) L1, a large cytoplasmic phosphatase also known as PTP-BAS/PTPN13/PTP-1E, is a negative

regulator of IGF-1R/IRS-1/Akt path-way in breast cancer cells.

19782949

GO:0004722

IEA

MGI:103305

GO:0016787 hydrolase activity/N/A

N/A

N/A

N/A

N/A

MGI:104597

GO:0016740 transferase activity/N/A

Using this assay system, chloramphenicol acetyltransferase activity directed by the cTNT promoter/upstream region was between two and three orders of magnitude higher in cardiac or skeletal muscle cells than in fibroblast cells, indicating that cis elements responsible for cell-specific expression reside in this region of the cTNT gene. Many Andersen syndrome cases have been associated with loss-of-function mutations in the inward rectifier K(+) channel Kir2.1 encoded by KCNJ2.

3047142

GO:0008811

GO:0016407

N/A

MGI:104744

GO:0022857 transmembrane transporter activity/GO:0005242 inward rectifier

potassium

channel activity

18690034

GO:0015267

IEA

MGI:104744

GO:0022892 substrate-specific transporter activity/GO:0005242 inward rectifier potassium

channel activity

IRK1, but not GIRK1/GIRK4 channels, showed a marked specificity toward phosphates in the 4,5 head group positions.

10593888

GO:0015267

IEA