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Figure 6 | BMC Bioinformatics

Figure 6

From: Three-Level Prediction of Protein Function by Combining Profile-Sequence Search, Profile-Profile Search, and Domain Co-Occurrence Networks

Figure 6

An example (CAFA target T30248) showing how DCN-based "aggregated neighbor-counting" method works. (A) Tertiary structure of target protein T30248 predicted by MULTICOM [35] (magenta: domain SEP; green: domain UBX). (B) Electrostatic of protein T30248, generated based on predicted structures in (A) (blue: positive; red: negative). (C) The main Domain Co-occurrence Networks (DCN) of Homo sapiens used to make function prediction. (D) Radius-one neighbor domains of the four domains - ubiquitin, UBX, SEP, and FERM_N - of the target. The GO terms of the neighboring domains were used as predictions for the target. Detailed discussion can be found in "Results and Discussion" section.

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BMC Bioinformatics

ISSN: 1471-2105

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