How to inherit statistically validated annotation within BAR+ protein clusters

BMC Bioinformatics

Table 2 Comparing UniProtKB direct annotation with BAR+ annotation

	CAFA/UniProtKB*		BAR+ Validated°
	Sequences	Terms	Sequences with validated annotation	Validated Terms	Sequences with new validated annotation
Total°	34,065	10,628	34,065	13,558	3,659^§
Pfam^	30,767	5,293	31,190	5,365	423^§
MFO^	20,790	2,048	21,758	2,698	968^§
BPO^	19,739	2,719	21,585	4,879	1,846^§
CCO^	16,503	568	17,589	616	1,086^§
-	-	-	3,451^#	5,886^#	3,451^#
PDB⁺	2,047⁺	-	13,084⁺	-	11,935⁺

*The CAFA/UniProt KB set (the CAFA sequences that have a UniprotKB file) comprises 41,003 sequences, 3,767 of which do not contain any GO ontology and Pfam terms. °Here the CAFA/UniProtKB subset that can be validated in BAR+ is considered (BAR+validated). The number of sequences and the number of Pfam and GO terms are listed. Sequences that receive new validated terms are also listed according to Pfam, MFO, BPO and CCO. ^# Sequences of the CAFA set, out of a total of 7,295 that are not present in UniProtKB and are annotated in BAR+. ⁺Number of sequences that have and also receive in BAR+ a PDB template.