TY - JOUR AU - Erdin, Serkan AU - Venner, Eric AU - Lisewski, Andreas Martin AU - Lichtarge, Olivier PY - 2013 DA - 2013/02/28 TI - Function prediction from networks of local evolutionary similarity in protein structure JO - BMC Bioinformatics SP - S6 VL - 14 IS - 3 AB - Annotating protein function with both high accuracy and sensitivity remains a major challenge in structural genomics. One proven computational strategy has been to group a few key functional amino acids into templates and search for these templates in other protein structures, so as to transfer function when a match is found. To this end, we previously developed Evolutionary Trace Annotation (ETA) and showed that diffusing known annotations over a network of template matches on a structural genomic scale improved predictions of function. In order to further increase sensitivity, we now let each protein contribute multiple templates rather than just one, and also let the template size vary. SN - 1471-2105 UR - https://doi.org/10.1186/1471-2105-14-S3-S6 DO - 10.1186/1471-2105-14-S3-S6 ID - Erdin2013 ER -