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Figure 5 | BMC Bioinformatics

Figure 5

From: Prediction of conformational epitopes with the use of a knowledge-based energy function and geometrically related neighboring residue characteristics

Figure 5

Example of predicted CE clusters and true CE. (A) Protein surface of KvAP potassium channel membrane protein (PDB ID: 1ORS:C). (B) Surface seed residues possessing energies within the top 20%. (C) Top three predicted CEs for 1ORS:C. Predicted CEs were obtained by filtering, region growing, and CE cluster ranking procedures. The filtering step removing neighboring residues located within 12 Å according to the energy ranked seed. Region growing formulated the CE cluster from previous filtered seed residues to extend neighboring residues within 10 Å radius. CE clusters were ranking by calculating the combination of weighted CEI and Energy scores. (D) Experimentally determined CE residues.

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BMC Bioinformatics

ISSN: 1471-2105

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