Two common epitope regions for GI and GII genogroup and the exclusive epitope region for GII genogroup. The spatial epitope of norovirus capsid protein. The 3D structure of norovirus capsid protein is displayed as the ribbon mode, and the common and exclusive spatial epitopes for GI and GII have been mapped to the 3D structure. Two common epitope regions (Epi 1: 298~305, Epi 2: 357~374) for GI and GII genogroup have been highlighted in yellow color and surface mode. The exclusive epitope region for GII genogroup (Epi_3: 395~406) has been highlighted with red color.