Table 3 Top 10 predicted causal genes of 16 multifactoral diseases predicted by DP-LCC
Phenotype Name | PhenoID | Top-10 predictions for each phenotype by our algorithm | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
Alzheimer disease | 104300 | PAH | TYROBP | TREM2 | MAPT | PSEN1 | SIGLEC14 | CD300E | NCR2 | CLEC5A | HLA-DQB1 |
Breast cancer | 114480 | PAH | DHCR24 | SMYD2 | SHISA5 | FBXO11 | MTM1 | TSC1 | TSC2 | MTMR12 | STK11 |
Colon cancer | 114500 | MLH1 | BRCA2 | MSH2 | PMS2 | VHL | DHCR24 | SHISA5 | SMYD2 | FBXO11 | EXO1 |
Diabetes mellitus | 125853 | ABCG8 | ABCG5 | PPP1R3A | RP1 | CFTR | B2M | F2 | APC | PLN | CD1E |
Gastric cancer | 137215 | MLH1 | PTCH2 | MSH2 | PMS2 | ESR1 | SMO | PTCH1 | EXO1 | PNLIP | IHH |
Atrial fibrillation | 147050 | RAG2 | RAG1 | CPN1 | IGF1R | KL | IL2 | IFNA1 | CPN2 | MEN1 | PRSS1 |
Prostate cancer | 176807 | TP53 | RET | DHCR24 | SMYD2 | SHISA5 | FBXO11 | STK11 | NTRK1 | CDKN2A | BCL7A |
Schizophrenia | 181500 | PAH | GLO1 | TYROBP | TREM2 | MAPT | MTM1 | MTMR12 | SIGLEC14 | CD300E | NCR2 |
Leukemia/lymphoma | 190685 | POMT1 | POMT2 | PAH | TYROBP | TREM2 | CHRNA1 | NSD1 | CHRNE | FGFR2 | CHRND |
Lung cancer | 211980 | TP53 | CDKN2A | SFTPA2 | SFTPA1 | ZFP91 | ZNF227 | TBRG1 | KIAA1984 | CDKN2AIP | ANKRD12 |
Zellweger syndrome | 214100 | PEX19 | ETFB | ETFA | PEX6 | PEX1 | PEX12 | POMT2 | POMT1 | SLC25A17 | PEX11A |
Leukemia | 253310 | BSCL2 | CHRNA1 | CHRNG | DOK7 | C5orf62 | TMEM19 | USE1 | CHRND | RAPSN | MUSK |
Asthma | 600807 | MARCO | SCGB3A1 | RFXAP | RFX5 | HPS1 | HPS4 | RFXANK | IL6 | MPO | IL2 |
Leukemia | 601626 | MPL | THPO | AMPD1 | PDGFRB | HES5 | FANCE | FANCD2 | BRCA2 | ATXN2L | MYH2 |
Obesity | 601665 | MC3R | ATRNL1 | MC1R | MC5R | ASIP | MC2R | NPY | NPY5R | SIGLEC6 | GHRHR |
Tuberculosis | 607948 | NDUFV2 | UMOD | HSPA4 | AGRP | ASIP | IFNGR2 | HPN | TUBA4A | GGCX | LTB |