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Table 3 Top 10 predicted causal genes of 16 multifactoral diseases predicted by DP-LCC

From: Prioritization of candidate disease genes by topological similarity between disease and protein diffusion profiles

Phenotype Name PhenoID Top-10 predictions for each phenotype by our algorithm
Alzheimer disease 104300 PAH TYROBP TREM2 MAPT PSEN1 SIGLEC14 CD300E NCR2 CLEC5A HLA-DQB1
Breast cancer 114480 PAH DHCR24 SMYD2 SHISA5 FBXO11 MTM1 TSC1 TSC2 MTMR12 STK11
Colon cancer 114500 MLH1 BRCA2 MSH2 PMS2 VHL DHCR24 SHISA5 SMYD2 FBXO11 EXO1
Diabetes mellitus 125853 ABCG8 ABCG5 PPP1R3A RP1 CFTR B2M F2 APC PLN CD1E
Gastric cancer 137215 MLH1 PTCH2 MSH2 PMS2 ESR1 SMO PTCH1 EXO1 PNLIP IHH
Atrial fibrillation 147050 RAG2 RAG1 CPN1 IGF1R KL IL2 IFNA1 CPN2 MEN1 PRSS1
Prostate cancer 176807 TP53 RET DHCR24 SMYD2 SHISA5 FBXO11 STK11 NTRK1 CDKN2A BCL7A
Schizophrenia 181500 PAH GLO1 TYROBP TREM2 MAPT MTM1 MTMR12 SIGLEC14 CD300E NCR2
Leukemia/lymphoma 190685 POMT1 POMT2 PAH TYROBP TREM2 CHRNA1 NSD1 CHRNE FGFR2 CHRND
Lung cancer 211980 TP53 CDKN2A SFTPA2 SFTPA1 ZFP91 ZNF227 TBRG1 KIAA1984 CDKN2AIP ANKRD12
Zellweger syndrome 214100 PEX19 ETFB ETFA PEX6 PEX1 PEX12 POMT2 POMT1 SLC25A17 PEX11A
Leukemia 253310 BSCL2 CHRNA1 CHRNG DOK7 C5orf62 TMEM19 USE1 CHRND RAPSN MUSK
Asthma 600807 MARCO SCGB3A1 RFXAP RFX5 HPS1 HPS4 RFXANK IL6 MPO IL2
Leukemia 601626 MPL THPO AMPD1 PDGFRB HES5 FANCE FANCD2 BRCA2 ATXN2L MYH2
Obesity 601665 MC3R ATRNL1 MC1R MC5R ASIP MC2R NPY NPY5R SIGLEC6 GHRHR
Tuberculosis 607948 NDUFV2 UMOD HSPA4 AGRP ASIP IFNGR2 HPN TUBA4A GGCX LTB