Table 1 ANOVA results of 19 variables contributing to Brucella vaccine protection efficacy
# | Variables | Df | Sum Square | Mean Square | F value | P-value (>F) |
|---|---|---|---|---|---|---|
Variables with statistically significant contribution to protection (P-value < 0.05) | ||||||
1 | CFU Reduction | 1 | 4.32 | 4.32 | 58.66 | 1.574E-13 |
2 | Pathogen challenge route | 1 | 2.20 | 2.20 | 29.90 | 8.278E-08 |
3 | Vaccine dose | 1 | 1.77 | 1.77 | 24.09 | 1.369E-06 |
4 | CFU in spleen | 1 | 0.92 | 0.92 | 12.49 | 4.591E-04 |
5 | Challenge Pathogen Strain | 1 | 0.85 | 0.85 | 11.54 | 0.0008 |
6 | Mouse strain | 1 | 0.58 | 0.58 | 7.86 | 0.0053 |
7 | Vaccine strain | 1 | 0.41 | 0.41 | 5.56 | 0.0188 |
8 | Vaccination route | 1 | 0.41 | 0.41 | 5.54 | 0.0190 |
9 | Challenge-killing Interval | 1 | 0.38 | 0.38 | 5.19 | 0.0232 |
Variables without statistically significant contribution to protection (P-value > 0.05) | ||||||
10 | Vaccination Frequency | 1 | 0.27 | 0.27 | 3.61 | 0.0581 |
11 | Adjuvant | 1 | 0.18 | 0.18 | 2.41 | 0.1215 |
12 | Vaccination Challenge Interval | 1 | 0.16 | 0.16 | 2.20 | 0.1385 |
13 | Gene Mutation | 1 | 0.12 | 0.12 | 1.68 | 0.1951 |
14 | Mouse Age at Vaccination | 1 | 0.07 | 0.07 | 0.97 | 0.3244 |
15 | Sample Size | 1 | 0.03 | 0.03 | 0.47 | 0.4928 |
16 | Vaccine viability | 1 | 0.02 | 0.02 | 0.34 | 0.5612 |
17 | Antigen Overexpression | 1 | 0.02 | 0.02 | 0.23 | 0.6299 |
18 | Mouse Sex | 1 | 0.01 | 0.01 | 0.10 | 0.7499 |
19 | Challenge Dose | 1 | 0.00 | 0.00 | 0.07 | 0.7988 |