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Figure 1 | BMC Bioinformatics

Figure 1

From: In silico investigation into dendritic cell regulation of CD8Treg mediated killing of Th1 cells in murine experimental autoimmune encephalomyelitis

Figure 1

Cell network model of CD8Treg mediated regulation within the ARTIMMUS EAE simulator. Computer simulations commence following immunization with MBP, which DCs subsequently engulf and present on MHC class II molecules to facilitate activation of MBP-specific encephalitogenic CD4Th1 cells. Effector CD4Th1 cells migrate to the CNS and initiate the autoimmune pathway (red solid arrows) through microglia induced killing of neurons (our computational abstraction of demyelination within EAE). Effector CD4Th1 cells undergo activation-induced cell death at the end of the cell lifecycle. Apoptotic CD4Th1 cells migrate out of the CNS, and are efferocytosed by CLN and spleen-resident DCs. They may also be efferocytosed in the CNS by DCs that migrate to the CLN upon maturation. These DCs present TCR peptides, which initiate the down-regulatory pathway (blue dashed arrows) through activation of CD4Treg cells and CD8Treg cells [5], and subsequent killing of the encephalitogenic CD4Th1 cells. On a population level, regulation of CD4Th1 cells leads to a type2 deviation [23], resulting in down-regulation of the autoimmune response. Adapted from [20].

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