Skip to main content
Figure 2 | BMC Bioinformatics

Figure 2

From: In silico investigation into dendritic cell regulation of CD8Treg mediated killing of Th1 cells in murine experimental autoimmune encephalomyelitis

Figure 2

Control dynamics of the ARTIMMUS simulator. Median population curves for effector CD4Th1, CD4Th2, CD4Treg and CD8Treg cells as total numbers across all spatial compartments. CD4Th1 cells rapidly proliferate approximately 3-4 days following immunization for EAE, peaking at approximately day 12. The population of CD4Treg cells begin to proliferate shortly before the peak in CD4Th1 cells is achieved. Due to their helper function on CD8Treg cells, these show a similar proliferative timecourse, although having smaller total numbers. Although the CD4Th2 cells compete with CD4Th1 cells and contribute to down-regulation of the autoimmune response, their total numbers are significantly lower than the encephalitogenic CD4Th1 cells. The majority of CD4Treg and CD8Treg cells are primed within the spleen (data not presented), and there are approximately 66% more CD4Treg than CD8Treg cells. The autoimmune response is complete and returns to a normal state shortly after day 60 (after Read [14]).

Back to article page

BMC Bioinformatics

ISSN: 1471-2105

Contact us