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Table 4 Chimeras detection in Body map 2.0 by FusionMap

From: State of art fusion-finder algorithms are suitable to detect transcription-induced chimeras in normal tissues?

Tissue

# of genes involved in chimeras in Body Map 2.0

# of genes also detected in the negative dataset

# of genes also detected as chimeras in[7]

Genes in chimeras[7]

Chimeras detected by FusionMap

Chimeras in[7]

Adipose

74

7

0

-

  

Adrenal

60

6

0

-

  

Brain

56

10

0

-

  

Breast

32

2

0

-

  

Colon

15

3

0

-

  

Kidney

37

4

0

-

  

Heart

18

0

0

-

  

Liver

31

2

1

HLA-E

HLA-E:BCKDHB

HLA-E:GSTP1

Lung

46

5

0

-

  

Lymph node

37

1

0

-

  

Prostate

68

12

0

-

  

Skeletal muscle

34

3

0

-

  

White blood cells

29

4

0

-

  

Ovary

30

3

1

SPP1

SPP1:ABCA10

RAMP2:SPP1

  1. Number of genes detected as part of chimera in Body Map 2.0 50 nts paired-end dataset. Body Map 2.0 50 nts paired-end was generated from the same donors used for the 75 nts single-end dataset used in Frenkel-Morgenstern's paper to validate putative fusion by means of a knowledge-based approach. Thus, the two datasets are technical replication of the same mRNA universe.
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BMC Bioinformatics

ISSN: 1471-2105

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