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Table 3 Pathway analysis of cDNA arrays

From: Scalable high-throughput identification of genetic targets by network filtering

Drug

SVM Pathways

MNI Pathways

Known MoA

Terbinafine

Ergosterol biosynthetic process (27)

Steroid metabolism (2130)

Inhibition of squalene monooxygenase, thus blocking the biosynthesis of ergosterol

Lovastatin

-

Lipid metabolism (16244)

Inhibition of HMG-CoA reductase

Itraconazole

Ergosterol biosynthetic process (256)

Steroid metabolism (2130)

Interaction with 14-α demethylase an enzyme necessary to convert lanosterol to ergosterol.

Hydroxyurea

Deoxyribonucleotide biosynthetic process (704)

Dna replication (5480)

Inhibition of ribonucleotide reductase and consequently of DNA synthesis

Tunicamycin

Cellular nitrogen compound catabolic process (6678), Protein targeting to ER (585)

Protein-ER targeting (585)

N-linked glycosylation