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Table 1 Preferred and avoided residues at different positions of amyloid and non-amyloid forming hexa-peptides

From: Distinct position-specific sequence features of hexa-peptides that form amyloid-fibrils: application to discriminate between amyloid fibril and amorphous β-aggregate forming peptide sequences

Position

Amyloid

Non-amyloid

Preferred

  

1

S, W, Y, H, M, N

F, H, K, S, W, Y

2

C, F, I, Q, T, Y

E, M, T, Y

3

F, Q, V, W

C, E, F, N, V, W

4

I, L, N, W, Y

F, I, L, Y

5

F, I, Y

F, I, Y

6

C, E, F, M, Q, S, Y

E, F, M, T, W

Avoided

  

1

D, T, R, E

G, L, A, Q, V

2

D, A, N, S, G

D, N, P, R

3

A, G, D, I, Y

A, G, R, T, Y

4

V, S, K, A

A, M, V, D, W

5

E, L, Q, S, T

A, G, M, R, S, T

6

A, D, G, I, K

A, V

  1. Bold letters indicate common amino acid residues in amyloid and non-amyloid.
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BMC Bioinformatics

ISSN: 1471-2105

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