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Table 2 Phyletic distribution of experimentally confirmed and hypothetical peptidase families in MEROPS clan MA

From: New mini- zincin structures provide a minimal scaffold for members of this metallopeptidase superfamily

Subclan Family Name Archaea Bacteria Eukaryota
Total phyla 5 28 49
MA(E) M1 Aminopeptidase N 3 21 31
  M2 Angiotensin-converting enzyme - 6 11
  M3 Thimet oligopeptidase 3 25 28
  M4 Thermolysin 1 10 4
  M5 Mycolysin - 2 -
  M9 Microbial collagenase 1 6 -
  M13 Neprilysin 1 12 23
  M26 IgA metalloendopeptidase 1 4 -
  M27 Tentoxilysin - 1 -
  M30 Hyicolysin 1 9 -
  M32 Carboxypeptidase Taq 5 16 7
  M34 Anthrax lethal factor - 1 -
  M36 Fungalysin - 6 5
  M41 FtsH endopeptidase - 27 36
  M47 Metallopeptidase PRSM1 - - 1
  M48 Metallopeptidase STE24 4 25 28
  M49 Dipeptidyl-peptidase III - 6 21
  M56 BlaR1 peptidase - 11 -
  M60 Enhancin - 3 1
  M61 Glycyl aminopeptidase 2 10 2
  M65 YugP protein (Bacillus) - 3 -
  M69 F19C6.4 protein (Caenorhabditis) - - 1
  M70 Surface protein (Ehrlichia) - 1 -
  M76 Atp23 peptidase - - 21
  M78 ImmA peptidase - 10 -
  M85 NleC peptidase - 1 -
  M90 MtfA peptidase - 9 -
  M91 NleD peptidase - 1 -
  M93 BACCAC_01431 protein (Bacteroides) - 1 -
  M95 Proabylysin 1 5 -
MA(M) M6 Immune inhibitor A 1 12 3
  M7 Snapalysin - 1 -
  M8 Leishmanolysin - 7 20
  M10 Matrix metallopeptidases 2 11 14
  M11 Autolysin - 2 2
  M12 Astacins/reprolysins 1 8 26
  M35 Deuterolysin - 3 3
  M39 YIL108W protein (Saccharomyces) - - 1
  M43 Cytophagalysin 1 6 14
  M54 Archaelysin 4 12 8
  M57 PrtB protein (Myxococcus) - 3 -
  M59 Putative zinc metalloprotease (Vibrio) - 1 -
  M62 Membrane metalloprotease (Euryarchaeota) 1 3 -
  M64 IgA peptidase (Clostridium) - 5 1
  M66 StcE peptidase - 3 1
  M68 JHP0742 protein (Helicobacter) 1 3 -
  M71 PAE0478 protein (Pyrobaculum) 1 - -
  M72 Peptidyl-Asp metallopeptidase - 7 1
  M80 Wss1 peptidase - - 12
  M83 DR2310 peptidase - 2 -
  M84 mpriBi peptidase 1 1 -
  M94 Acel_2062 protein (Acidothermus) -- 9 -
  1. Families are ordered by subclan and name. The number of phyla in each of the superkingdoms Archaea, Bacteria and Eukarya from which at least one homologue is known are shown. Where the number of phyla exceeds half the known phyla in the superkingdom, the number is highlighted in bold. The family in each subclan with examples from the most phyla in each superkingdom is shown as bold, italics text. A hyphen indicates no examples are known in that superkingdom. Rows in italics are families of putative peptidases that have not yet been experimentally characterized as such. The MEROPS identifier for such a family is provisional and may be subject to change.