Table 2 Centre genes identified in top-1000/500 SNPs interactions on AMD dataset
From: Cloud computing for detecting high-order genome-wide epistatic interaction via dynamic clustering
# Genes per | Centre genes from gene-only SNP analyses | |
|---|---|---|
interaction | Centre genes | # Interacting genes |
| Â | CFH: complement factor H | 777 |
| Â | ZNF25: zinc finger protein 25 | 23 |
2 | SGCD: sarcoglycan, delta (35kDa dystrophin-associated glycoprotein) | 23 |
| Â | LRIG3: leucine-rich repeats and immunoglobulin-like domains 3 | 14 |
| Â | DRD1: dopamine receptor D1 | 11 |
| Â | ISCA1: iron-sulfur cluster assembly 1 | 11 |
| Â | CFH: complement factor H | 815 |
| Â | DRD1: dopamine receptor D1 | 63 |
3 | ATM: ataxia telangiectasia mutated | 47 |
| Â | GPC5: glypican 5 | 43 |
| Â | NPAT: nuclear protein, ataxia-telangiectasia locus | 34 |
| Â | KDM4C: lysine (K)-specific demethylase 4C | 25 |
| Â | CFH: complement factor H | 459 |
| Â | ATM: ataxia telangiectasia mutated | 191 |
4 | NPAT: nuclear protein, ataxia-telangiectasia locus | 115 |
| Â | LRIG3: leucine-rich repeats and immunoglobulin-like domains 3 | 73 |
| Â | TGFBR2: transforming growth factor, beta receptor II (70/80kDa) | 38 |
| Â | ACP1: acid phosphatase 1, soluble | 35 |