MUBII general organization. The MUBII-TB-DB database and the de novo constructed mutation database (orange frame) are built before the query session. The mutation database is used for the results interpretation and for the construction of the BLAST mutation database. Ovals indicate the use of external software (dark green) or of MUBII routines (pale green). The query analysis process (green frame) combines the BLAST result and the expertise of the alignment using the mutation database. Outputs are in blue.