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Table 1 Comparison among m-HMM with and without change point adjustment, and original HMM in simulation study 1

From: Copy number variation detection using next generation sequencing read counts

  

m-HMM

m-HMM no adj.

original HMM

Gain

Sensitivity

0.917

0.915

0.863

EFNR

0.097

0.174

0.751

Normal

Specificity

0.996

0.994

0.945

EFPR

0.002

0.002

0.003

Loss

Sensitivity

0.858

0.831

0.826

EFNR

0.309

0.434

0.846

Absent

Sensitivity

0.960

0.857

0.810

EFNR

0.011

0.005

0.000

  1. Sensitivities and empirical false negative rates for copy number gain, loss and absent states, as well as specificities and empirical false positive rates for the normal state in the first simulation study.
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BMC Bioinformatics

ISSN: 1471-2105

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