Skip to main content

Table 1 Comparison among m-HMM with and without change point adjustment, and original HMM in simulation study 1

From: Copy number variation detection using next generation sequencing read counts

   m-HMM m-HMM no adj. original HMM
Gain Sensitivity 0.917 0.915 0.863
EFNR 0.097 0.174 0.751
Normal Specificity 0.996 0.994 0.945
EFPR 0.002 0.002 0.003
Loss Sensitivity 0.858 0.831 0.826
EFNR 0.309 0.434 0.846
Absent Sensitivity 0.960 0.857 0.810
EFNR 0.011 0.005 0.000
  1. Sensitivities and empirical false negative rates for copy number gain, loss and absent states, as well as specificities and empirical false positive rates for the normal state in the first simulation study.