Figure 12

The hierarchical similarity graph. Creation of the hierarchical similarity graph of gene sets: (a) the source gene sets, (b) the gene-set bipartite graph, (c) the gene-set bipartite graph with two of its maximal bicliques highlighted, ({DRD2},{GS1256,GS1132}) and ({NPY,PDYN,CYP2D6},{GS1132,GS1229}), and (d) integration of all maximal bicliques to a DAG of function relationships. In this graph, the two highlighted maximal bicliques from (b) are roots. The maximal biclique ({25 genes},{GS1132}) is a child of both, since {GS1132} is a subset of the gene sets in both roots. Geneset {GS1132} is associated with the genes DRD2 and NPY, PDYN, CYP2D6 as its parents, but is also connected to 21 genes not shown.