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Table 7 Top parameters used in KD4i (ranked according to their percent usage in the rules), DDIG-in and SIFT-Indel

From: A comprehensive study of small non-frameshift insertions/deletions in proteins and prediction of their phenotypic effects by a machine learning method (KD4i)

KD4i DDIG-in SIFT-Indel
Disorder Probability Probability of disorder Fraction of Pfam domains
Indel in a Pfam domain Solvent accessible surface area Indel in a repeat
Conserved amino acid DNA conservation score 1 Indel in a disordered region
Relative solvent accessible surface area DNA conservation score 2 DNA conservation score
Local perturbation in volume (average) Sheet/amino acid conservation score 1 -