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Table 7 Top parameters used in KD4i (ranked according to their percent usage in the rules), DDIG-in and SIFT-Indel

From: A comprehensive study of small non-frameshift insertions/deletions in proteins and prediction of their phenotypic effects by a machine learning method (KD4i)

KD4i

DDIG-in

SIFT-Indel

Disorder Probability

Probability of disorder

Fraction of Pfam domains

Indel in a Pfam domain

Solvent accessible surface area

Indel in a repeat

Conserved amino acid

DNA conservation score 1

Indel in a disordered region

Relative solvent accessible surface area

DNA conservation score 2

DNA conservation score

Local perturbation in volume (average)

Sheet/amino acid conservation score 1

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