Table 2 Summarizing the inferred melanoma cancer clusters
From: Identifying pathogenic processes by integrating microarray data with prior knowledge
Cluster | Size | Upreg. (%) | Edges | Priors (%) | Top three GO terms |
|---|---|---|---|---|---|
1 | 130 | 2.3 | 16770 | 1.3 | Epidermis development, cornified envelope, keratinization |
2 | 25 | 4.0 | 600 | 0.0 | Androgen biosynthetic process, extracellular region, desmosome |
3 | 28 | 3.6 | 756 | 1.7 | Forebrain morphogenesis, response to vitamin A, negative regulation of neuron maturation |
4 | 25 | 0.0 | 600 | 1.2 | Keratinization, peptide cross-linking, desmosome |
5 | 17 | 52.9 | 272 | 1.8 | Testosterone 16-alpha-hydroxylase activity, negative regulation of Rho GTPase activity, |
negative regulation of epidermal growth factor-activated receptor activity | |||||
6 | 13 | 61.5 | 156 | 1.9 | Alcohol sulfotransferase activity, CDP-diacylglycerol biosynthetic process, embryonic |
hindgut morphogenesis | |||||
7 | 13 | 53.8 | 156 | 1.3 | Regulation of mesonephros development, negative regulation of cell proliferation involved |
in mesonephros development, negative regulation of fibroblast growth factor receptor | |||||
signaling pathway involved in ureteric bud formation | |||||
8 | 12 | 0.0 | 132 | 0.0 | Glutamate dehydrogenase (NAD+) activity, glutamate dehydrogenase [NAD(P)+] activity, |
negative regulation of myelination | |||||
9 | 12 | 16.7 | 132 | 1.5 | Serine-type endopeptidase activity, serine hydrolase activity, peptidase activity, acting on |
L-amino acid peptides | |||||
10 | 10 | 50.0 | 90 | 0.0 | Adherens junction organization,interleukin-1 Type I receptor binding, dihydrotestosterone |
17-beta-dehydrogenase activity | |||||
11 | 10 | 0 | 90 | 1.1 | N-acylglucosamine 2-epimerase activity, osteoclast proliferation, alkaloid catabolic process |
12 | 10 | 30.0 | 90 | 0.0 | Middle ear morphogenesis, vagus nerve morphogenesis, activation of phospholipase |
D activity by G-protein coupled receptor protein signaling pathway | |||||
13 | 11 | 9.1 | 110 | 0.9 | Scavenger receptor activity, negative regulation of collateral sprouting of intact axon |
in response to injury, regulation of cell adhesion | |||||
14 | 11 | 0.0 | 110 | 0.9 | Positive regulation of cell development, regulation of cell morphogenesis involved in |
differentiation, argininosuccinate synthase activity | |||||
15 | 12 | 16.7 | 132 | 0.0 | Pharynx development, cellular response to external biotic stimulus, nucleus |
16 | 9 | 0.0 | 72 | 1.4 Alpha-dystroglycan binding, isopeptide cross-linking via N6-(L-isoglutamyl)-L lysine, | |
positive regulation of arachidonic acid secretion | |||||
17 | 7 | 100.0 | 42 | 14.3 | Vascular transport, interleukin-1 Type II blocking receptor activity, Golgi cis cisterna |
18 | 6 | 66.7 | 30 | 3.3 | NLRP1 inammasome complex, 17-alpha,20-alpha-dihydroxypregn-4-en-3-one |
dehydrogenase activity, androsterone dehydrogenase (B-specific) activity |