Figure 1

Sense making model for exploring molecular level influences on disease-related processes. Our model presents analysts’ progressive and cumulative sources of data for constructing and representing knowledge on the y-axis and their progressive units (or focus) of analysis on the x-axis. It names stages by users’ analysis objectives not by information artifacts as in the Pirolli and Card model; and it ties stages/objectives to domain content. It also includes validation questions analysts iteratively investigate (arrow chains from higher to lower stages); and output from each stage that serves as input for the next.