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Figure 2 | BMC Bioinformatics

Figure 2

From: H2rs: Deducing evolutionary and functionally important residue positions by means of an entropy and similarity based analysis of multiple sequence alignments

Figure 2

Distribution of U vNE () values for one pair of residue positions. The histogram (blue) shows the distribution of the U vNE (k*, l*) values of the first two residue positions of ssTrpC resulting from shuffling the content of columns k and l of the MSA. A normality test on this distribution failed (P = 0.991), which indicates that the distribution is not Gaussian. The corresponding cumulative distribution is shown in black. The cumulative Gumbel distribution with parameters μ and β deduced from 25 randomization tests is shown in green. The red line depicts the actual U vNE value of this pair of residue positions. The orange line shows the U vNE value this pair would need to surpass a p-value of 0.01.

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