Figure 5From: H2rs: Deducing evolutionary and functionally important residue positions by means of an entropy and similarity based analysis of multiple sequence alignmentsecDHFR residues with highest conz ( k ) - values. For ecDHFR, H2rs predicted 6 residues with conz(k)-values ≥ 2.0 and p-values ≤ 10-11, which are shown as red sticks. The ligands folic acid and NADP are shown as green sticks.Back to article page