BicSPAM methodology: major dimensions. Principles to guarantee that BicSPAM approaches are scalable, flexible and robust to noise are addressed according three major steps. The mapping step defines the level and properties of the noise allowed through different discretization criteria and strategies to handle outliers and missing values. The core step, mining, defines structural performance aspects through the selection and parameterization of SPM methods. Finally, the closing step groups post-processing decisions to improve the quality and/or flexibility of biclustering solutions. BicSPAM methodology, thus, provides a roadmap to design and understand how the options associated to each step affect the performance of pattern-based approaches.