Discovery of order-preserving biclusters with symmetries. For each iteration the sign of expression of every row (or column) is coherently aligned in order to guarantee the consistency of signs for a target column (or row). Illustrating, x2 and x3 vectors were multiplied by -1 factor to guarantee the consistency of signs for y1 column. The target biclustering approach is then applied over this revised matrix. Iterations end when all the sign combinations have been covered.