Table 2 Single node and edge differences found between FTLD-U with progranulin mutation and control groups
From: Investigating perturbed pathway modules from gene expression data via structural equation models
Path | Type | FTLD-U Progranulin (P) | Control (C) | Difference (95% CI) | P-value | up/down |
|---|---|---|---|---|---|---|
1742 ← group | Group on node | -6.024 | -5.540 | -0.484(-0.87; -0.10) | 0.014 | P down-expressed |
5532 ← group | Group on node | 9.606 | 10.706 | -1.101 (-1.64; -0.56) | 0.000 | P down-expressed |
2785 ← group | Group on node | 8.453 | 9.734 | -1.281 (-1.95; -0.62) | 0.000 | P down-expressed |
5534 ← group | Group on node | 7.233 | 8.308 | -1.075 (-1.65; -0.51) | 0.000 | P down-expressed |
gtp_bind ← group | Group on node | 2.374 | 2.626 | -0.252 (-0.44; -0.06) | 0.000 | P down-expressed |
2911 < - > 9454 | Binding/association | 0.178 | 0.813 | -0.635 (-1.27; -0.00) | 0.049 | P down-regulated |
3708 < -9456 | Binding/association | 0.457 | -0.205 | 0.662 (0.34; 0.98) | 0.000 | P up-regulated |
ade_cycl < -gtp_bind | activation | -2.044 | -0.840 | -1.204 (-2.28; -0.13) | 0.028 | P down-regulated |
5613 < -107 | Indirect | -0.012 | -0.324 | 0.312 (0.02; 0.60) | 0.034 | P up-regulated |
5613 < -ade_cycl | Indirect | 0.446 | -0.413 | 0.858(0.43; 1.20) | 0.000 | P up-regulated |
5579 < -plc_b | Indirect | 3.677 | 1.110 | 2.567(0.86; 4.28) | 0.003 | P up-regulated |
22941 < -1742 | String | 1.306 | 0.570 | 0.736(0.12; 1.35) | 0.002 | P up-regulated |
plc_b < -9229 | Directed path | 0.262 | 0.558 | -0.297(-0.56; -0.03) | 0.028 | P down-regulated |
ade_cycl < -5532 | Directed path | -0.463 | 0.208 | -0.671(-1.16; -0.18) | 0.007 | P down-regulated |
ade_cycl < -5534 | Directed path | -0.713 | -0.168 | -0.545(-1.05 -0.05) | 0.032 | P down-regulated |
5613 < -22941 | Directed path | -0.581 | -0.039 | -0.542(-0.95; -0.13) | 0.010 | P down-regulated |
22941 < -glutam_recp | Directed path | 0.044 | -0.278 | 0.322(0.09; 0.55) | 0.006 | P up-regulated |
9455 < -glutam_recp | Directed path | -0.128 | -0.462 | 0.334(0.04; 0.92) | 0.024 | P up-regulated |