Table 3 Not significant (null edge) in FTLD-U with progranulin mutation and in control groups
From: Investigating perturbed pathway modules from gene expression data via structural equation models
| Â | Â | Progranulin (P) | Control (C) | Â | ||
|---|---|---|---|---|---|---|
Paths | Type | Estimate | P-value | Estimate | P-value | P/C |
2911 < -5534 | Activation | -0.024 | 0.238 | 0.232 | 0.927 | OFF/OFF |
gtp_bind < -2911 | Activation | -0.049 | 0.167 | -0.138 | 0.500 | OFF/OFF |
1742 < -glutam_recp | Binding/association | -0.192 | 0.008 | -0.376 | 0.200 | ON/OFF |
50944 < -9229 | Binding/association | 0.131 | 0.138 | 0.160 | 0.282 | OFF/OFF |
22941 < -9229 | Binding/association | -0.245 | 0.811 | -0.034 | 0.276 | OFF/OFF |
9456 < -22941 | Binding/association | -0.114 | 0.632 | 0.130 | 0.553 | OFF/OFF |
9456 < -50944 | Binding/association | 0.742 | 0.133 | 0.931 | 0.098 | OFF/OFF |
9455 < -22941 | Binding/association | 0.142 | 0.224 | -0.407 | 0.042 | OFF/ON |
9454 < -50944 | Binding/association | 0.519 | 0.466 | 0.226 | 0.358 | OFF/OFF |
3708 < -9455 | Binding/association | -0.322 | 0.067 | -0.137 | 0.432 | OFF/OFF |
3708 < -9454 | Binding/association | 0.462 | 0.055 | 0.216 | 0.001 | OFF/ON |
107 < -gtp_bind | Activation | 0.198 | 0.525 | 0.136 | 0.743 | OFF/OFF |
plc_b < -gtp_bind | Activation | -0.275 | 0.225 | -0.234 | 0.127 | OFF/OFF |
5613 < -107 | Indirect | -0.012 | 0.000 | -0.324 | 0.926 | ON/OFF |
1742 < -50944 | String | 0.971 | 0.013 | 1.166 | 0.062 | ON/OFF |
3708 < -2911 | String | -0.068 | 0.054 | 0.143 | 0.501 | OFF/OFF |
9229 < -50944 | String | -0.490 | 0.116 | -1.755 | 0.502 | OFF/OFF |
ade_cycl < -5532 | Directed path | -0.463 | 0.169 | 0.208 | 0.022 | OFF/ON |
ade_cycl < -5534 | Directed path | -0.713 | 0.107 | -0.168 | 0.003 | OFF/ON |
glutam_recp < -5532 | Directed path | -0.531 | 0.000 | -1.017 | 0.061 | ON/OFF |
5579 < -9456 | Directed path | 0.228 | 0.000 | 0.654 | 0.470 | ON/OFF |
5579 < -5534 | Directed path | 0.295 | 0.000 | 0.986 | 0.388 | ON/OFF |
5613 < -22941 | Directed path | -0.581 | 0.741 | -0.039 | 0.001 | OFF/ON |
22941 < -glutam_recp | Directed path | 0.044 | 0.000 | -0.278 | 0.696 | ON/OFF |
3708 < -22941 | Directed path | 0.264 | 0.000 | 0.443 | 0.072 | ON/OFF |
1742 < -9229 | String | -0.626 | 0.027 | -1.399 | 0.126 | ON/OFF |