Figure 3

Interaction and enrichment analysis of the novel miRNA. a. The interaction of novel miRNAs with various signaling molecules reveals positive and negative regulation with downstream effector molecules as shown by MetaCore analysis. Red arrow indicates a down regulation whereas green arrow indicates up regulation of a particular pathway by the given miRNA ( generic binding protein; microRNA; - Transcription factor; - receptor ligand; - generic enzyme; - protein and - regulators). b. Histogram representing enrichment analysis of these novel miRNAs in different diseased conditions in humans. c. The spectrum of novel miRNAs involved in GM-CSF signaling. d & e. Enrichment analysis of miRNAs and their targets shows the list of different signaling networks they are involved and are deregulated in different carcinomas.