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Table 1 Lists the experimentally validated novel microRNAs and their putative targets in different signaling pathways at EL −25 ΔG kcal/mol

From: OncomiRdbB: a comprehensive database of microRNAs and their targets in breast cancer

a.  
Novel miRNA Targets(Jak-Stat)
hsa-miR-193b-5p SOCS-2, AKAP13, AKT2, BCL2L1, CLCF1, IL10RA, IL10RB, JAK3, LIF, PIAS4,PIK3R2, PIK3R5, PRLR, PTPN11, SOCS7, STAT5B, TSLP, TYK2
hsa-miR-296-3p AKT2, BCL2L1, CSF3, GRB2, IFNGR2, IL10RA, IL11, IL11RA, IL9R, PIK3CB, PIK3R2, PIK3R5,PRKAR2A, PTPN6, STAT5A, STAT6, TSLP, TYK2
hsa-miR-296-5p CREBBP, GRB2, PIAS2, PTPN11, SOCS3, STAT6
hsa-miR-339-3p IL20RA, SOCS2, STAT5A, CLCF1, GH2, GHR, IL2RB, IL4R, IL6R, LIF
hsa-miR-491-5p CBLB, CISH, CSF3R, PIK3R2, PTPN6, SOCS7, SPRY4, TYK2, AKT1, IKBKG, PIK3R5, SERF2, AKAP13, CSF3, IFNAR2, IL15RA, IL2RB, IRF9, LEP, PIK3R5, PRLR, SOCS2, SPRY3, STAT6, STS
hsa-miR-623 AKAP13, AKT2, BCAS1, CSF3, CSF3R, GRB2, IFNAR2, IL10RA, IL11RA, IL28RA, IL4R, IL6ST, PIK3R2, PIK3R5, SASH1, SOCS3, SPRY4, STAT5A, STAT6, TYK2
hsa-miR-639 CCND1, IL2RB, PIAS4, PRLR, AKAP13, BCL2L1, CBL, CISH, CNTFR, CSF2RB, CSF3, GRB2
hsa-miR-770-5p IL4R, PIK3R3, AKAP13, AKT2, CBL, CNTFR, CSF3, IL11RA, IL6ST, IL7R, PIK3R5, PTPN11, SOCS2, STAT5A, STAT5B, STAT6, STS, TYK2
hsa-miR-941 CSF2RA, CTF1, IFNAR1, IFNAR2, IL10RA, IL10RB, IL11RA, IL28RA, LIF, OSM, PIK3CA, PIK3R2, PRKAR2A, PRLR, STAT5A, SOCS3, SPRED2
hsa-miR-15a-3p BCAS1, FZD4, PIK3R1, AKAP13, BCAS1, CISH, CSF2, CSF3R, GRB2, IL13, IL13RA1, STAT5A, TYK2
hsa-miR-141-5p AKT2, BCL2, PRKAR1B, TRAF2, XIAP, CISH, IL22RA2, PIK3R3, PIM1, STAT2, STAT6
hsa-miR-148b-5p IFNAR2, JAK1, DFFA, IFNAR2, JAK1
hsa-miR-17-3p EXOG, IRAK3, TRAF2, CBL, STAT1 IL15RA, IL19, STAT6
hsa-miR-188-3p AKT1, OSMR, SPRY2, SPRY4, CCND1,IL10RA, CBLB, CISH, CNTFR, CSF2RB, IL13, IL13RA1, IL6, IL9R, PTPN6, SPRY3, STAT3, TYK2
hsa-miR-218-2-3p AKAP13, AKT2, PIM1, STAT5A, TYK2, CSF2RB, CSF3R
hsa-miR-219-1-3p EXOG, AKAP13, AKAP13, IL7R, PIM1, SPRY3, TSLP, IL11, IL13RA1, MATR3, IL19
hsa-miR-24-1-5p PIK3R1, IL19, CSF2RB, DFFB, PIK3R1, NRG1
hsa-miR-329 SOCS2, IL10RA, IL4R, GRB2, IFNAR2, IL11RA , JAK3
hsa-miR-337-5p AKT2, CBL, IL10RB, TNFRSF10B, AKAP13, AKT1, CSF2RB, IL10RA, IL13RA1, PIK3R5, STAT6, CTF1, IL28RA, JAK3, STAT5A, STAT5B, STS, TYK2 , MVP
hsa-miR-506-3p PIAS2, STAT5A, CCND2
hsa-miR-519e-3p AKT2, AKT1, STAT3, STAT5A, IKBKG, NF2
hsa-miR-521 AKT1, PIK3R1, STAT5A, CBL, CCND2
hsa-miR-550a-3p AKT1, CSF3, JAK3, STAT3, CASP7, DFFA, DFFB, EXOG, IKBKB, IRAK4, PPP3R1, PRKAR2A, IL10RA, IL28RA, IL2RB, PRKAR2A, IL6R
hsa-miR-617 IL11, IL19, IL4R, LIF, PRLR, SOCS7, IL15, IL6R, AKT2, IL21R, STAM2, STAT3, IKBKG, XIAP
hsa-miR-644a AKAP13
hsa-miR-934 CSF3, IL11RA, LIF, PTPN11, SOCS2, PIK3R2, AKT3, OSM, TYK2, APAF1, CASP7, IL1R1, SERF2, TRAF2
hsa-miR-147b XIAP, PIK3CG, STAT5B, CCND1, CCND3, CISH, CLIC6, IL19, JAK1, SPRED1, TYK2
hsa-miR-33a-3p IL15, EXOG
hsa-miR-146b-5p AKT1
hsa-miR-19a-5p CBL
hsa-miR-26a-1-3p AKT2, TYK2, PIAS3
hsa-miR-493-5p AKAP13, KIT
hsa-miR-562 IKBKB, ADAM17, NMI, TGFB1, TNFSF13B, PTK2, AKT2, CSF3, KIT
b.  
Novel miRNA Targets (MAPK) Targets(NOTCH) Targets (VEGF) Targets (Wnt)
hsa-miR-296-3p F2RL1, NFATC2, EPHB4 EPHB4 F2RL1, NFATC2 NFATC2, VANGL1
hsa-miR-296-5p APC, CSPG4 - AQP1 ZEB2, APC
hsa-miR-339-3p WEE1, FLNA - - CACYBP
hsa-miR-491-5p PDGFRA, XIAP, KAT6B - LRP6, PDGFRA XIAP, LRP6
hsa-miR-770-5p - MAGEA1 RBM39 -
hsa-miR-941 - - STAT5A -
hsa-miR-15a-3p ARF1, WNT5A - RBL2 SETD8, WNT5A, VIM
hsa-miR-141-5p FLOT1 - IL17F SULF1
has-miR-148b-5p LRP1 - LRP1, KCNH1, DNMT1 LRP1, PLCB2
has-miR-17-3p CXADR, DUSP22, PLK1 GDPD5 PLK1 -
has-miR-188-3p YWHAZ MUC16, GLI1 GLI1, PIK3R2, PIK3R2 GLI1
has-miR-218-2-3p FGF4, TNC - TNC CSNK1E, PLCB2
has-miR-219-1-3p NOS2 - NOS2 CHST11
has-miR-24-1-5p NRG1 - NRG1 -
has-miR-329 CDH13 JAK3 JAK3 -
has-miR-337-5p RARA, MVP, DUSP22, VEGFA, ABCA1, GRIN1, MAPK12, F10, BCL6, IGFBP5 CDKN1A, NCSTN, VEGFA, WNT3A VEGFA, MAZ, LIMK1, MAPK12, F10, COL1A1, PIK3R1, IL15, IGFBP5 AXIN2, MBD2, CDH11, WNT3A, BCL6
has-miR-506-3p - - - CCND2
has-miR-519e-3p NFKB2, RARA, NF2, TFF2, ARRB2 ARRB2 - ARRB2, NF2
has-miR-521 - - NFATC1 NFATC1
has-miR-550a-3p DYNLL1, IL6R LFNG IL6R, IL15 ING4, SFRP5
has-miR-617 OCLN, LRP1, NDFIP1, TIMP1 NCOR1 OCLN, MMP2, LRP1, TIMP1, ARF6 LRP1, TIMP1
has-miR-644a - - - CUX1
has-miR-934 KCNMA1 GLI1 GLI1, APEX1 GL1
has-miR-33a-3p FLT4 FLT4 FLT4 AXIN1
has-miR-146b-5p NFATC2, XIAP - NFATC2 XIAP, NFATC2
has-miR-26a-1-3p AGER, ERBB, ACAT1, CXCR2, PRMT1, SMAD3, APOBEC3G, RRAS, PLAUR, LRP1, PGR, ERBB3, MAPK12, TRAF4, NOS3, NOTCH4, PLAUR, FURIN AGER, NOS3, NOTCH4, PARG, PLAUR, ERBB3, LRP1, CD47, MAPK12, FURIN, SMAD3 LRP1, ERBB3, MCC, SCN5A, PRMT1, ZNF703, SMAD3
has-miR-493-5p PODXL, GRIN1, KIT, TGFB3 - MUC1, KIT FERMT2, IGF2BP1, PLCB2
has-miR-562 CDH5, PTK2, FLNA, SP1, CSF3, TGFB1, NFATC2, CD36, ERCC1, ADAM17, ARRB1, NGFR, HSPB1, MAP3K11, PTK2, TNFSF13B, APOB, KIT, CSF3, AKT2, TRAF2, ELK1, CD274, CAMK2B ADAM17, ARRB1, TGFB1 ADAM17, APOB, HSPB1, PTK2, CSF3, AKT2, CDH5, TGFB1, NFATC2, PPARA, VASH1, SP1, KIT CHST11, TGFB1, NMI, FXYD5, NFATC2, CAMK2B
  1. a. The genes targeted by these miRNAs in the Jakstat pathway. b. represents those genes targeted in Mapkinase, Notch,Vegf and Wnt signaling pathways.