ROC curve of an improved Caller B built by fitting a logistic model using the mutation quality score and individual filters of Caller B. Model fitting was done using the point mutations in 243 genes of interest from 174 patients excluding the 20 patients, and evaluation was done on the point mutations in the 20 selected patients. The performances of three individual callers (red filled triangles), the combined caller that cumulatively adds mutation sets (connected blue dots), and the combined caller by fitting the logistic model (green lilne) are shown for comparison purposes. ROC curves of two updated versions of Caller B are shown. One version is obtained by ranking the mutations detected by Caller B using the mutation quality score of Caller B (violet line), and the other version by fitting a logistic model using the mutation quality score and the individual filters of Caller B on an extended set of mutations that were detected by at least one of the three callers (orange line).