Figure 1

Correspondence between the distance map of ( S )-mandelate dehydrogenase (sMDH) X-ray structure [PDB:1HUV] and the covariation maps for the MDH protein family obtained with different methods. Contact predictions by 2D_MI (light blue), 3D_MI (red), 4D_MI (black), PSICOV (blue), plmDCA (green), GREMLIN (cyan), and hpPCA (magenta) are shown as spots of size proportional to the covariation score. Gray regions represent the native distance map of the sMDH X-ray structure with a cutoff of 8 Å on the distance between the centroids of different residues.