MCIA projection plot. (A) The first two axes of MCIA represent transcriptomic and proteomic datasets of the NCI-60 panel. Different shapes represent the respective platforms and are connected by lines where the length of the line is proportional to the divergence between the data from a same cell line. Lines are joined by a common point, representing the reference structure which maximizes covariance derived from the MCIA synthetic analysis. Colors represent the nine NCI-60 cell lines from different tissues. The epithelial and mesenchymal features are separated along the first axis (PC1, horizontal). Melanoma and leukemia cell lines were projected on the negative side of second axis (PC2, vertical). (B) Summarizing the concordance between platforms by representing pseudo-eigenvalue space of NCI-60 datasets. The pseudo-eigenvalue space represents overall co-structure between datasets and shows which platform contributes more to the total variance.