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Figure 7 | BMC Bioinformatics

Figure 7

From: On the necessity of dissecting sequence similarity scores into segment-specific contributions for inferring protein homology, function prediction and annotation

Figure 7

Domain architectures of the 10 false (false-positive) hits. The domain architectures of 5 Pfam domain models (PF01298.13 Lipoprotein5, PF05134.8 T2SL, PF09110.6 HAND, PF10390.4 ELL) revealed that the 10 hits (1:IF2P_HUMAN, 2:IF2P_MOUSE, 3:IF2P_PONAS, 4:NUCL2_ORYSJ, 5:KMT2D_MOUSE, 6:CORTO_DROME, 7:DHKL_DICDI, 8:AMOT_MOUSE, 9:NUCL_HUMAN, 10:PK4_DICDI) are falsely associated to the respective domain models through a significant non-structural segment which is typically low-complexity and disordered.

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BMC Bioinformatics

ISSN: 1471-2105

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