Figure 2

Illustration of the proposed compartment models. Panel A illustrates a compartment model where the drug is assumed to induce cell cycle arrest with halving time $T_{0c}^1$ and for cells in cell cycle arrest the death rate is assumed exponential with halving time $T_{1c}^{†}$. Panel B illustrates a simplified compartment model in which the drug is assumed to induce cell death with halving time $T_c^{†}$. In both models the cell line grows with doubling time T₀. Panel C illustrates growth curves according to Model B for a cell line with T₀ = 60 hours and N₀ = 30,000 cells treated with three different concentrations of a potent drug. The concentrations correspond to the summary statistics G I₅₀ = c₁, TGI =c₂, and LC₄₈ = c₃.