Exposure time independent summary statistics for assessment of drug dependent cell line growth inhibition

Falgreen, Steffen; Laursen, Maria Bach; Bødker, Julie Støve; Kjeldsen, Malene Krag; Schmitz, Alexander; Nyegaard, Mette; Johnsen, Hans Erik; Dybkær, Karen; Bøgsted, Martin

doi:10.1186/1471-2105-15-168

BMC Bioinformatics

Table 2 Summary of the simulation study

From: Exposure time independent summary statistics for assessment of drug dependent cell line growth inhibition

	Mean bias			Standard deviation			MSE
	GI ₅₀	TGI	LC ₄₈	GI ₅₀	TGI	LC ₄₈	GI ₅₀	TGI	LC ₄₈
Cell line 1, T ₀ = 60
Time 25	0.01	0.04	0.07	0.49	0.49	0.22	0.24	0.24	0.05
Time 49	-0.07	-0.06	0.00	0.36	0.36	0.14	0.13	0.14	0.02
Time 73	-0.05	-0.05	-0.01	0.25	0.25	0.11	0.06	0.07	0.01
Cell line 2, T ₀ = 30
Time 25	-0.10	-0.08	-0.01	0.41	0.41	0.24	0.17	0.17	0.06
Time 49	-0.04	-0.04	-0.02	0.18	0.19	0.13	0.03	0.04	0.02
Time 73	-0.02	-0.02	-0.01	0.11	0.12	0.09	0.01	0.01	0.01
Cell line 3, T ₀ = 15
Time 25	-0.05	-0.04	-0.02	0.21	0.25	0.21	0.05	0.06	0.05
Time 49	-0.01	-0.01	0.00	0.08	0.11	0.10	0.01	0.01	0.01
Time 73	-0.02	-0.01	0.00	0.07	0.09	0.08	0.01	0.01	0.01
Cell line 4, T ₀ = 15
Time 25	-0.02	0.00	0.01	0.20	0.22	0.20	0.04	0.05	0.04
Time 49	-0.01	0.00	0.00	0.09	0.11	0.10	0.01	0.01	0.01
Time 73	-0.04	-0.04	-0.03	0.10	0.11	0.11	0.01	0.01	0.01
Cell line 5, T ₀ = 30
Time 25	-0.08	-0.06	0.00	0.43	0.43	0.23	0.19	0.19	0.05
Time 49	-0.03	-0.03	-0.01	0.17	0.18	0.12	0.03	0.03	0.01
Time 73	-0.03	-0.03	-0.01	0.12	0.13	0.09	0.02	0.02	0.01
Cell line 6, T ₀ = 60
Time 25	-0.07	0.00	0.07	0.69	0.63	0.23	0.47	0.40	0.06
Time 49	-0.08	-0.06	0.00	0.41	0.38	0.14	0.18	0.15	0.02
Time 73	-0.04	-0.03	0.00	0.25	0.23	0.10	0.06	0.06	0.01
Cell line 7, T ₀ = 15
Time 25	-0.05	-0.03	-0.02	0.22	0.24	0.20	0.05	0.06	0.04
Time 49	-0.02	-0.01	0.00	0.09	0.11	0.10	0.01	0.01	0.01
Time 73	-0.10	-0.11	-0.04	0.22	0.23	0.10	0.06	0.06	0.01
Cell line 8, T ₀ = 60
Time 25	-0.10	-0.03	0.06	0.73	0.65	0.22	0.54	0.42	0.05
Time 49	-0.14	-0.09	-0.02	0.49	0.41	0.15	0.26	0.18	0.02
Time 73	-0.06	-0.05	-0.01	0.29	0.27	0.11	0.09	0.08	0.01
Cell line 9, T ₀ = 30
Time 25	-0.09	-0.06	0.00	0.46	0.44	0.23	0.22	0.20	0.05
Time 49	-0.04	-0.03	-0.01	0.17	0.19	0.12	0.03	0.04	0.02
Time 73	-0.02	-0.02	-0.01	0.11	0.12	0.08	0.01	0.01	0.01

The mean bias, standard deviation, and mean squared error of the summary statistics GI₅₀, TGI, and LC₄₈ obtained by the G-model for the 1,000 simulated datasets and the three time points.

Back to article page

ISSN: 1471-2105

Contact us

General enquiries: journalsubmissions@springernature.com