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Table 2 Summary of the simulation study

From: Exposure time independent summary statistics for assessment of drug dependent cell line growth inhibition

  Mean bias   Standard deviation   MSE
  GI 50 TGI LC 48   GI 50 TGI LC 48   GI 50 TGI LC 48
Cell line 1, T 0 = 60            
Time 25 0.01 0.04 0.07   0.49 0.49 0.22   0.24 0.24 0.05
Time 49 -0.07 -0.06 0.00   0.36 0.36 0.14   0.13 0.14 0.02
Time 73 -0.05 -0.05 -0.01   0.25 0.25 0.11   0.06 0.07 0.01
Cell line 2, T 0 = 30            
Time 25 -0.10 -0.08 -0.01   0.41 0.41 0.24   0.17 0.17 0.06
Time 49 -0.04 -0.04 -0.02   0.18 0.19 0.13   0.03 0.04 0.02
Time 73 -0.02 -0.02 -0.01   0.11 0.12 0.09   0.01 0.01 0.01
Cell line 3, T 0 = 15            
Time 25 -0.05 -0.04 -0.02   0.21 0.25 0.21   0.05 0.06 0.05
Time 49 -0.01 -0.01 0.00   0.08 0.11 0.10   0.01 0.01 0.01
Time 73 -0.02 -0.01 0.00   0.07 0.09 0.08   0.01 0.01 0.01
Cell line 4, T 0 = 15            
Time 25 -0.02 0.00 0.01   0.20 0.22 0.20   0.04 0.05 0.04
Time 49 -0.01 0.00 0.00   0.09 0.11 0.10   0.01 0.01 0.01
Time 73 -0.04 -0.04 -0.03   0.10 0.11 0.11   0.01 0.01 0.01
Cell line 5, T 0 = 30            
Time 25 -0.08 -0.06 0.00   0.43 0.43 0.23   0.19 0.19 0.05
Time 49 -0.03 -0.03 -0.01   0.17 0.18 0.12   0.03 0.03 0.01
Time 73 -0.03 -0.03 -0.01   0.12 0.13 0.09   0.02 0.02 0.01
Cell line 6, T 0 = 60            
Time 25 -0.07 0.00 0.07   0.69 0.63 0.23   0.47 0.40 0.06
Time 49 -0.08 -0.06 0.00   0.41 0.38 0.14   0.18 0.15 0.02
Time 73 -0.04 -0.03 0.00   0.25 0.23 0.10   0.06 0.06 0.01
Cell line 7, T 0 = 15            
Time 25 -0.05 -0.03 -0.02   0.22 0.24 0.20   0.05 0.06 0.04
Time 49 -0.02 -0.01 0.00   0.09 0.11 0.10   0.01 0.01 0.01
Time 73 -0.10 -0.11 -0.04   0.22 0.23 0.10   0.06 0.06 0.01
Cell line 8, T 0 = 60            
Time 25 -0.10 -0.03 0.06   0.73 0.65 0.22   0.54 0.42 0.05
Time 49 -0.14 -0.09 -0.02   0.49 0.41 0.15   0.26 0.18 0.02
Time 73 -0.06 -0.05 -0.01   0.29 0.27 0.11   0.09 0.08 0.01
Cell line 9, T 0 = 30            
Time 25 -0.09 -0.06 0.00   0.46 0.44 0.23   0.22 0.20 0.05
Time 49 -0.04 -0.03 -0.01   0.17 0.19 0.12   0.03 0.04 0.02
Time 73 -0.02 -0.02 -0.01   0.11 0.12 0.08   0.01 0.01 0.01
  1. The mean bias, standard deviation, and mean squared error of the summary statistics GI50, TGI, and LC48 obtained by the G-model for the 1,000 simulated datasets and the three time points.