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Figure 1 | BMC Bioinformatics

Figure 1

From: Large-scale combining signals from both biomedical literature and the FDA Adverse Event Reporting System (FAERS) to improve post-marketing drug safety signal detection

Figure 1

Data and experimental flowchart. The two large data sources for drug-SE extraction are 4,285,094 records from FAERS and 21,354,075 MEDLINE records. The process included: (1) drug-SE pair extraction from FAERS; (2) Ranking extracted pairs using six commonly used statistical signal detection approaches, and boosting the rankings by pairs’ MEDLINE presence; and (3) manual curation of all targeted anticancer drug associated cardiovascular events that appeared in both FAERS and MEDLINE and compared them to those captured in FDA drug labeling.

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BMC Bioinformatics

ISSN: 1471-2105

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