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Figure 3 | BMC Bioinformatics

Figure 3

From: Scan for Motifs: a webserver for the analysis of post-transcriptional regulatory elements in the 3′ untranslated regions (3′ UTRs) of mRNAs

Figure 3

Scan for motifs’s interactive graphical output for the vertebrate Tumor Necrosis Factor (TNF) 3′UTRs, using the settings shown in Figure2. Known protein and miRNA sites are detected, and additional predictions are made. The experimentally confirmed and conserved ARE mRNA stability elements are shown in the centre (~710-740, yellow). These are flanked by TargetScan miRNA target predictions (red), miR-19a and miR-181a are known to target these sites. The miR-130 TargetScan prediction almost completely overlaps the miR19 site (left, two intensities of red). Some of the additional predictions include patterns of lower specificity (green and blue) are not conserved and may be false positives (e.g. the KHSRP protein binding site to the left (green ~670), or the miR-150-5p (blue ~760). However miR-125 (blue 8mer seed match ~690) does target this UTR. The results can be downloaded for further study (upper right). See the Results and Discussion section for further analysis.

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BMC Bioinformatics

ISSN: 1471-2105

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