Figure 4

Working in teams. The diagram shows users and groups with their respective pools (blue lines). The users 1 and 2 are members of “Team a” with user 1 as coordinator. The users 3 and 4 belong to the group “Team b” and here user 3 is the coordinator. Furthermore, users 1, 3 and 4 are part of the group “Actin Nucleation” (users 1 and 4 are coordinators). The continuous black lines denote the memberships. Following the dashed arrows, user 1 imports into its private pool a manually curated list of human genes involved in actin nucleation (a) and publishes its protein interaction network to the group “Actin Nucleation” (b). Using orthology mapping user 3 translates the interaction network into another species (c) and publishes it to the group “Team b” (d). User 4 copies this list to his private pool (e), manually curates it (f) and publishes this new list to the group “Actin Nucleation” (g). The new list is published to group “Team a” by user 1 (h) and user 2 copies it to his private pool (i).