Figure 1

Tail Schematic. Schematic of possible tails created by reads representing a deletion (a) and an inversion (c) allele and the structural variants they represent when mapped to the reference (b). Rectangles represent double-stranded genomic sequence. Arrows above and below a rectangle represent reads mapping to the direct and complement strands, respectively. In these examples, all initial alignments align at the 5’ breakpoint of the reference. The read spanning a deletion event creates an epilog that maps to the 3’ breakpoint on the same strand as its corresponding initial alignment. The reads spanning the inversion event breakpoints create prologs that map on the opposite strands of their corresponding initial alignment. While all three piece-alignments would cluster if we considered only their location, their orientations support two separate events in the reference region.