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Table 2 Sample size determination: here, D = 3 and 4 , and n is the sample size for each class satisfying: VUS ( ) ̂ VUS ( n ) ̂ < γ ( = 0.01 )

From: Determination of sample size for a multi-class classifier based on single-nucleotide polymorphisms: a volume under the surface approach

  n
D h m = 30 m = 50 m = 100 m = 200
3 0.05 1957 2040 2091 2040
3 0.1 489 475 412 288
3 0.15 189 161 105 69
4 0.05 1923 2051 2137 2122
4 0.1 490 476 417 297
  1. Here, θ 1 = ( θ 1 , 1 , , θ 1 , m ) , let θ1,jU(0.4,0.49),j=1,…,m; for a specified scalar value h, let h 1 , h 2 , h 3 be such that their components hi,jU(h−0.002,h+0.002), j=1,…,m; and let θ i + 1 = θ i h i ,i=1,2,3; m is the number of independent SNPs, α=0.01 is the significant level for Wald tests; and ρ=1 is the percentage of the significant SNPs.