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Table 2 Numbers of significant CpGs (q-value < 0.05) according to five different tests

From: Phenotype prediction based on genome-wide DNA methylation data

 

Normal

Normal HPV+

Normal HPV-

CIN2+(a)

CIN2+(b)

Cancer

t

0

0

0

389

233

14811

0

0

0

452

100

10383(7)

0

0

0

8

140

4753(1)

MWU

0

0

0

403

1008

16990

0

0

0

408

372

11320(97)

0

0

0

10

646

5885(46)

Bartlett

2830

1837

1204

3035

3444

12023

1614

1154

748

2208

1948

12209

1194

707

468

847

1489

414

Levene

0

0

0

241

2

5881

0

1

0

326

4

7178

0

0

0

0

0

80

Age-corr.

16

385

68

13

89

473

16

330

75

19

52

525

 

1

49

13

5

31

69

  1. t-test, Mann–Whitney U test, Bartlett’s test, Levene’s test and test for methylation-age-correlation. The three rows per cell correspond to all, hyper- and hypo-CpGs. Numbers of most significant CpGs that are completely separating cases from controls are given in brackets.