Figure 5

Heatmaps of RPMM cluster analysis using top 1000 filtered features by TM-GOF (A,C) or SD-b (B,D) methods using 95 kidney cancer-non-cancer samples (data set #4). Rows represent features and columns represent samples; yellow represents high DNA methylation and blue represents low. The color bars at the top of the columns indicate sample tissue types (row 1) and clusters (row 2). In row 1 dark and light green indicate cancer and non-cancer samples, respectively. In row 2 red, yellow, blue and green bars indicate the sample clusters found after two divisions of clustering using RPMM. Figure A &B show heatmaps of all 95 kidney samples using top 1000 features filtered by TM-GOF or by SD-b method, respectively. Figures C &D show heatmaps of 50 kidney tumors using top 1000 features filtered by TM-GOF or by SD-b method, respectively. In C, the blue and green bar clusters are found at the second separation.