Figure 1

Plot of differential expression for glioblastoma edge and core cells. Negative Log₁₀p-values for each of the 805 miRs were plotted on the y-axis and Log₂ normalized fold change expression levels on the x-axis. The threshold Benjamini-Hochberg corrected -Log₁₀p-value (1.687) is superimposed on the volcano plot for reference (horizontal dashed line) to identify miRs with significant differential expression (α = 0.05). Vertical dashed lines at -1.0 and 1.0 Log₂ fold change represent twofold threshold values. Black dots represent the 64 miRs identified as exhibiting both a significant FDR corrected p-value and a ≥ twofold change in expression level.