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Figure 1 | BMC Bioinformatics

Figure 1

From: Exploiting large-scale drug-protein interaction information for computational drug repurposing

Figure 1

Schematic bit-string representation of a drug-human protein interaction profile. Each protein is represented by 3 bits to encode drug binding, drug activation, and drug inhibition of the protein, respectively. When a drug has been reported or predicted to bind, activate, or inhibit a protein, the bit representing the specific drug-protein interaction is turned on (assigned a value of 1). Otherwise, the bit is off (assigned a value of 0). M denotes the number of drugs with an approved indication (positive class), N denotes the total number of drugs, f i represents on-bit or off-bit of the i-th bit feature, A i denotes the number of on-bits of the i-th bit feature in the positive class, and B i denotes the number of on-bits of the i-th bit feature in all drugs.

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