Impact of false positive on the performance of type II models. The models were built with one to three true positives and either zero or one false positive. Error bars represent 1 standard deviation from full cross-validation calculations. The random bar heights represent the expected fractions of positive drugs in 1%, 5%, and 10% randomly picked baseline compounds. Models constructed with no false positives correspond to type II models (Figure 3,D-F). A: High blood pressure (HBP) model. B: Human immunodeficiency virus (HIV) model. C: antimalarial model. TP: true positive. FP: false positive.