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Table 2 Therapeutic information of the drugs assigned to the baseline class that were scored highest by the hypertension model a

From: Exploiting large-scale drug-protein interaction information for computational drug repurposing

Generic name Score Information from DrugBankb Information from other sources
Nitrendipine 103.9 For mild to moderate hypertension.  
Nimodipine 93.9 For use as an adjunct to improve neurologic outcome following subarachnoid hemorrhage. A 1998 clinical study [33] observed that nimodipine reduces systolic and diastolic blood pressures of the central retinal artery and therefore may provide another therapeutic choice for pregnancy-induced hypertension.
Alprenolol 69.7 For hypertension, angina, and arrhythmia.  
Nilvadipine 69.2 For vasospastic angina, chronic stable angina, and hypertension.  
Oxprenolol 69.1 For the treatment of hypertension, angina pectoris, arrhythmias, and anxiety.  
Norepinephrine 53.8 For patients in vasodilatory shock states, also used as a vasopressor medication for patients with critical hypotension.  
Spirapril 52.1 An ACE inhibitor for hypertension.  
Lercanidipine 46.5 For hypertension, angina pectoris, and Raynaud’s syndrome.  
Yohimbine 44.7 Used as a mydriatic and for the treatment of impotence.  
Epinephrine 43.9 Used in asthma and cardiac failure and to delay absorption of local anesthetics. A systematic review in 2002 [34] found that the use of epinephrine in uncontrolled hypertensive patients was associated with small, non-significant increases in systolic and diastolic blood pressure.
  1. aThe model was developed with all 55 drugs in the National Institutes of Health hypertension drug list in the positive class; the remaining drugs and drug development candidates were potential repurposing candidates in the baseline class.
  2. bRef. [26].
  3. ACE: angiotensin-converting enzyme.