Table 4 Therapeutic information of the drugs assigned to the baseline class that were scored highest by the malaria model a
From: Exploiting large-scale drug-protein interaction information for computational drug repurposing
Generic name | Score | Information from DrugBankb | Information from other sources |
|---|---|---|---|
Dexamethasone | 22.1 | An anti-inflammatory 9-fluoro-glucocorticoid. | Dexamethasone was reported to have a dramatic life-saving effect on people with cerebral malaria [44]. However, two subsequent placebo-controlled clinical trials failed to demonstrate clinical benefit [45, 46]. |
Verapamil | 21.5 | A calcium channel blocker for hypertension, angina, and cluster headache prophylaxis. | A 1995 study [48] reported that verapamil reverses chloroquine resistance in the malaria parasite. |
Quercetin | 18.9 | A flavonol found in plants, antioxidant. | A 2012 study [47] reported that quercetin had antiplasmodial activity. |
Miconazole | 16.5 | An imidazole antifungal agent. | Many studies [39–43] have reported antimalarial activities of antifungal azole compounds. |
Clotrimazole | 15.9 | An imidazole derivative with a broad spectrum of antimycotic activity. | Many studies [39–43] have reported antimalarial activities of azoles, including clotrimazole [43]. |
Cimetidine | 15.5 | For acid-reflux disorders (GERD), peptic ulcer disease, heartburn, and acid indigestion. | A 1997 study [49] reported synergism of cimetidine with antimalarial agents. It is ineffective when used alone. |
Ketoconazole | 15.2 | For systemic fungal infections. | Many studies [39–43] have reported antimalarial activities of azoles, including ketoconazole [41]. |
Nifedipine | 14.9 | A calcium channel blocker for angina, hypertension, and Raynaud's phenomenon. | |
Tamoxifen | 14.4 | For breast cancer. | |
Clobetasol | 14.4 | For corticosteroid-responsive dermatoses of the scalp. |