Skip to main content

Table 4 Therapeutic information of the drugs assigned to the baseline class that were scored highest by the malaria model a

From: Exploiting large-scale drug-protein interaction information for computational drug repurposing

Generic name Score Information from DrugBankb Information from other sources
Dexamethasone 22.1 An anti-inflammatory 9-fluoro-glucocorticoid. Dexamethasone was reported to have a dramatic life-saving effect on people with cerebral malaria [44]. However, two subsequent placebo-controlled clinical trials failed to demonstrate clinical benefit [45, 46].
Verapamil 21.5 A calcium channel blocker for hypertension, angina, and cluster headache prophylaxis. A 1995 study [48] reported that verapamil reverses chloroquine resistance in the malaria parasite.
Quercetin 18.9 A flavonol found in plants, antioxidant. A 2012 study [47] reported that quercetin had antiplasmodial activity.
Miconazole 16.5 An imidazole antifungal agent. Many studies [3943] have reported antimalarial activities of antifungal azole compounds.
Clotrimazole 15.9 An imidazole derivative with a broad spectrum of antimycotic activity. Many studies [3943] have reported antimalarial activities of azoles, including clotrimazole [43].
Cimetidine 15.5 For acid-reflux disorders (GERD), peptic ulcer disease, heartburn, and acid indigestion. A 1997 study [49] reported synergism of cimetidine with antimalarial agents. It is ineffective when used alone.
Ketoconazole 15.2 For systemic fungal infections. Many studies [3943] have reported antimalarial activities of azoles, including ketoconazole [41].
Nifedipine 14.9 A calcium channel blocker for angina, hypertension, and Raynaud's phenomenon.  
Tamoxifen 14.4 For breast cancer.  
Clobetasol 14.4 For corticosteroid-responsive dermatoses of the scalp.  
  1. aThe model was developed with all 11 antimalarial drugs in the positive class; the remaining compounds were potential repurposing candidates in the baseline class.
  2. bRef. [26].