Table 5 Structures and therapeutic information of tranexamic acid and the highest-scored drugs by the tranexamic acid model a
From: Exploiting large-scale drug-protein interaction information for computational drug repurposing
Structure | Generic name | Score | DrugBank indicationb | Information from other sources |
|---|---|---|---|---|
| Tranexamic Acid | For preventing hemorrhage in trauma and for excessive bleeding during and following tooth extraction, surgery, and menstruation. | The only drug used to build the DPIR prediction model. | |
| Aminocaproic acid | 1.39 | For the treatment of excessive postoperative bleeding. | |
| Amiloride | 1.38 | For use as adjunctive treatment with thiazide diuretics or other kaliuretic-diuretic agents in congestive heart failure or hypertension. | Amiloride was evaluated as a treatment for ameliorating trauma-hemorrhagic shock-induced lung injury in rats [53]. |
… 26 experimental drugs with scores between 1.38 and 0.69 …. | ||||
| Diethylstilbestrol | 0.69 | For treatment of prostate cancer and prevention of miscarriage or premature delivery in pregnant women prone to miscarriage or premature delivery. | Diethylstilbestrol was found to have particular clinical value in the treatment of certain functional gynecic aberrations. One of these is excessive or prolonged functional uterine bleeding [54]. |
