Figure 2

Organizing the data example. In our example, the protein has 5 residues with mutations. The residues are sorted from largest to smallest (so residue 1 has the largest number of mutations, residue 2 the second largest number of mutations, etc.), and the inside of the table is calculated as the sum of the mutations on both residues using all the samples in the study. For instance, as residue 1 has 50 mutations and residue 2 has 40 mutations, there were 90 total samples that had a mutation either on residue 1 or 2. In the actual code, only the lower half of the table is considered and then only sequentially to decrease running time, but we present the whole table here for clarity.